https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15688 Wed 11 Apr 2018 16:09:19 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:6547 Wed 11 Apr 2018 15:10:36 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16815 fl/fl with Zp3-cre+ mice, or in ovarian granulosa cells and uterine stroma by crossing with Amhr2-Cre+ mice. Surprisingly, deletion of STAT3 in oocytes had no effect on fertility indicating that the abundance of STAT3 protein in maturing oocytes and fertilized zygotes is not essential to these developmental stages. In Stat3^fl/fl;Amhr2-cre+ females impaired fertility was observed through significantly fewer litters and smaller litter size. Ovulation rate, oocyte fertilization and development to blastocyst were unaffected in this line; however, poor recombination efficiency in granulosa cells had yielded no net change in STAT3 protein abundance. In contrast, uteri from these mice showed STAT3 protein depletion selectively from the stomal compartment. A significant reduction in number of viable fetuses on gestational day 18, increased fetal resorptions and disrupted placental morphology were evident causes of the reduced fertility. In conclusion, this study defines an important role for STAT3 in uterine stromal cells during embryo implantation and the development of a functional placenta.]]> Wed 11 Apr 2018 15:06:51 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15099 Wed 11 Apr 2018 14:49:33 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14928 Wed 11 Apr 2018 10:08:24 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36499 D) and their embryos (7.0–42.3 cm W_D) and also yolks and histrotroph, to assess the potential implications for juvenile nutrition and habitat use. Irrespective of their development in the uterus, embryos had similar δ¹³C values in their muscle tissue as the mothers and both had greater values than in the histotroph. During gestation, δ¹³C values increased across all sample types. However, while embryo muscle tissue and the histotroph were associated with increasing ¹⁵N levels during embryonic development, this was depleted in the mothers’ muscle tissue and yolk. Although speculative, the observed variation in stable‐isotope ratios might imply a dietary shift among gravid females during their early gestation. Irrespective of the underlying mechanisms, the results indicate neonates will have relatively greater δ¹⁵N values than post‐partum females, which would probably confound juvenile foraging‐ecology estimates.]]> Tue 26 May 2020 13:53:17 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:11438 Sat 24 Mar 2018 08:14:35 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20202 Sat 24 Mar 2018 08:06:49 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:6585 Sat 24 Mar 2018 07:49:10 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:6584 Sat 24 Mar 2018 07:49:10 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30521 Sat 24 Mar 2018 07:25:04 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22266 Sat 24 Mar 2018 07:17:33 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33931 Mon 23 Sep 2019 13:28:19 AEST ]]>